太阳集团2007官网入口

  农业生物技术国家重点实验室

学术报告

 

 

题目：How do T cells see the metal antigens?

报 告 人：Prof. Dr. Shaodong Dai (National Jewish Health)

时间： 7月28日（星期二）上午9：30

地点：中国农业大学西区生命科学大楼二层2018

 

 

Prof. Dr Shaodong Dai简历

 

EDUCATION/TRAINING

 

 

POSITIONS:

1992-1993     Research Engineer, Beijing Clone Biomedical Technology Corporation, Beijing, P.R.CHINA

1993-1999     Graduate research assistant, Department of Molecular Biology, Uppsala Biomedical Centre, Swedish University of Agricultural Sciences, Uppsala, Sweden

1999-2001     Postdoctoral Research Associate, Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette.

2001-2008       Instructor and Crystallography Facility Manager, Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health

2008-2014       Assistant Professor, Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Health

2014-present   Associate Professor, Department of Biomedical Research (Formerly Integrated Department of Immunology), National Jewish Health

 

Review Activities:

Section Editor of protein structure in chemical sciences for Amino acids

 

Lead Guest Editor for Clinical and Developmental Immunology

 

Ad hoc reviewer, Proceedings of the National Academy of Sciences

Ad hoc reviewer, Acta Crystallographica Section D

Ad hoc reviewer, Photosynthesis Research

Ad hoc reviewer, Mini-Reviews in Medicinal Chemistry

Ad hoc reviewer for The Plant Journal

Ad hoc reviewer for PLOS one

Ad hoc reviewer for Nature Communications

 

Selected publications:

1.    Dai S, Saarinen M, Ramaswamy S, Meyer Y, Jacquot JP, Eklund H.  1996.  Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 Å resolution.  J Mol Biol 264:1044-57.

2.    Dai S, Schwendtmayer C, Schürmann P, Ramaswamy S and Eklund H.  2000.  Redox signaling in chloroplasts:  Cleavage of disulfides by an iron-sulfur cluster.  Science 287:655-8.

3.    Dai S, Vaillancourt FH, Maaroufi H, Drouin NM, Neau DB, Snieckus V, Bolin JT and Eltis LD.  2002.  Identification and analysis of a bottleneck in PCB biodegradation.  Nat Struct Biol 9:934-9.

4.    Fremont DH, Dai S, Chiang H, Crawford F, Marrack P and Kappler J.  2002.  Structural basis of cytochrome c presentation by IE^k.  J Exp Med 195:1043-52.

5.    Liu X, Dai S, Crawford F, Fruge R, Marrack P and Kappler J.  2002.  Alternate interactions define the binding of peptides to the MHC molecule IA^b.  Proc Natl Acad Sci USA 99:8820-5.

6.    Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S and Zhang G.  2003.  Lingand-receptor binding revealed by the TNF family member TALL-1.  Nature 423:49-56.

7.    Liu X, Dai S, Zhu Y, Marrack P and Kappler J.  2003.  The structure of a Bcl-x_L/Bim fragment complex.  Implications for Bim function.  Immunity 19:341-52.

8.    Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y and Zhang G.  2006.  Structural insights into histone demethylation by JMJD2 family members.  Cell 125:691-702.

9.    Dai S*, Friemann R, Glauser DA, Bourquin F, Manieri W, Schürmann P and Eklund H.  2007.  Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase.  Nature 4487:92-6.*Corresponding author

10.  Peyerl FW, Dai S, Murphy GA, Crawford F, White J, Marrack P and Kappler JW.  2007.  Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex.  Cell Death Differ 14:447-52.

11.  Dai S, Huseby ES, Rubtsova K, Scott-Browne J, Crawford F, Macdonald WA, Marrack P and Kappler JW.  2008.  Crossreactive T cells spotlight the germline rules for T cell-receptor interactions with MHC molecules.  Immunity 28:324-34.

12.  Dai S, Crawford F, Marrack P, and Kappler JW. 2008. The Structure of HLA-DR52C: comparison with other HLA-DRb3 isotypes. Proc Natl Acad Sci USA 105(33):11893-7

13.  Rubtsova K, Scott-Browne J, Crawford F, Dai S, Marrack P and Kappler JW. 2009. Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions. Proc Natl Acad Sci USA 106(19):7951-6

14.  Dai S*, Murphy GA, Crawford F, Mack DG, Martin AK, Marrack P, Kappler JW* and Fontenot AP*. 2010. Crystal structure of HLA DP2: implications for chronic beryllium disease. Proc Natl Acad Sci U S A. 107(16):7425-30 * Corresponding author

15.  Hong X, Zang J, White J, Wang C, Pan CH, Zhao R, Dai S, Zhang G.  2010. Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A.107(33):14568-72.

16.  Yin, L, Huseby ES, Rubtsova K, Scott-Browne J, Marrack P, Dai S* and Kappler JW*. 2011. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers. Immunity.35(1):23-33.*Corresponding author, equal contribution

17.  Yin, L, Crawford, F, Marrack P, Kappler JW*, and Dai S*, 2012. TCR interaction with peptides that mimic Ni++ offers insight into allergic Ni++ recognition  Proc Natl Acad Sci USA 109(45):18517-22 *Corresponding author

18.  Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. 2014. Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S*, Kappler JW*, 2014. Cell. 158(1):132-42. *Corresponding author

 

 

 

 

欢迎各位老师和同学参加！

 

 

 

联系人：陈忠周

 

7/19/2015